FaCD Online Syndrome Fact Sheet

Last updated: 12 Jun 2008

Name: Chronic Myelocytic Leukemia, Familial Clustering of

Synonym: Familial CML, incl.: Familial Chronic Myelocytic Leukemia-Like Syndrome, Familial Chronic Neutrophilic Leukemia

Mode of Inheritance: AD?/ AR?/ multifact?

Tumor features

chronic neutrophilic leukemia
leukemia, chronic myeloid (CML)

Comment

Familial clustering of CML has been observed, but is relatively rare[1,2]. Kojima et al.[2] reported a father and son with chronic neutrophilic leukemia, a subtype of CML. The father had been exposed to radioactive fallout and the authors considered the possibility of a radiation induced genetic damage associated with increased leukemia risk, transmitted from father to son.

References

[1] Lillicrap DA, Sterndale H. Familial chronic myeloid leukaemia. Lancet 1984; 22:699.
[2] Avilés A, Sinco A, Zapata N, Ambriz R, Pizzuto J. [Familial chronic myelogenous leukemia. Report of 3 cases in a family]. Sangre 1982; 27(5):953-8.
[3] Kojima K, Yasukawa M, Hara M, Nawa Y, Kimura Y, Narumi H, Fujita S. Familial occurrence of chronic neutrophilic leukaemia. Br J Hematol 1999; 105:428-430.