FaCD Online Syndrome Fact Sheet

Last updated: 27 Oct 2009

Name: Chondrosarcoma and Breast Cancer

Mode of Inheritance: de novo? multifact? spor?

Tumor features

breast cancer


It has been suggested that the combined occurrence of breast cancer and chondrosarcoma, single cases in families, is a distinct syndrome not related to germline mutations in TP53, CHEK2 and BRCA1/2[1,2].


[1] Cleton-Jansen AM, Timmerman MC, van de Vijver MJ, van Asperen CJ, Kroon HM, Eilers PH, Hogendoorn PC. A distinct phenotype characterizes tumors from a putative genetic trait involving chondrosarcoma and breast cancer occurring in the same patient.Lab Invest. 2004 Feb;84(2):191-202.
[2] Guedin P, Chasle J, Blanc-Fournier C, Lacroix J. [Breast carcinoma and bone chondrosarcoma: a new syndrome?][Article in French] J Radiol. 2006 Nov;87(11 Pt 1):1700-4.